Kimantawa game da fallasa ga 4,4′-methylene-bis-(2-chloroaniline) "MOCA" a wurin aiki ta hanyar wata sabuwar hanya mai mahimmanci don sa ido kan halittu

An samar da wata sabuwar hanyar nazari, wacce aka siffanta ta da takamaiman bayani da kuma ƙarfin fahimta, don tantance 4,4′-methylene-bis-(2-chloroaniline), wanda aka fi sani da "MOCA," a cikin fitsarin ɗan adam. Yana da mahimmanci a lura cewa MOCA wani abu ne da aka rubuta da kyau game da cutar kansa, tare da hujjoji masu ƙarfi da ke tabbatar da cewa tana da cutar kansa a cikin dabbobin dakin gwaje-gwaje kamar beraye, beraye, da karnuka.

Kafin amfani da wannan sabuwar hanyar da aka ƙirƙiro a yanayin aiki na zahiri, ƙungiyar binciken ta fara gudanar da wani bincike na farko na ɗan gajeren lokaci ta amfani da beraye. Babban manufar wannan binciken kafin asibiti shine gano da kuma fayyace wasu muhimman halaye da suka shafi fitar da fitsarin MOCA a cikin samfurin dabbobi - gami da fannoni kamar yawan fitar da fitsari, hanyoyin rayuwa, da kuma lokacin da za a iya gano matakan da za a iya ganowa - wanda hakan ya sanya harsashin kimiyya mai ƙarfi don amfani da hanyar a cikin samfuran ɗan adam.

Bayan kammalawa da kuma tabbatar da binciken da aka yi kafin a fara aiki, an yi amfani da wannan hanyar gano fitsari a hukumance don tantance girman yadda ma'aikata ke kamuwa da MOCA a wurin aiki a tsakanin ma'aikata a masana'antun masana'antu na Faransa. Tsarin binciken ya ƙunshi manyan nau'ikan yanayi biyu na aiki waɗanda ke da alaƙa da MOCA: ɗaya shine tsarin samar da masana'antu na MOCA da kanta, ɗayan kuma shine amfani da MOCA a matsayin maganin warkarwa a cikin kera polyurethane elastomers, yanayin aikace-aikacen da aka saba yi a masana'antar sinadarai da kayan aiki.

Ta hanyar babban gwajin samfuran fitsari da aka tattara daga ma'aikata a cikin waɗannan yanayi, ƙungiyar bincike ta gano cewa matakan fitar da fitsari na MOCA sun nuna bambance-bambance iri-iri. Musamman ma, yawan fitar da fitsari ya kama daga matakan da ba za a iya gano su ba - waɗanda aka ayyana a matsayin ƙasa da microgram 0.5 a kowace lita - zuwa matsakaicin microgram 1,600 a kowace lita. Bugu da ƙari, lokacin da aka sami metabolites na N-acetyl na MOCA a cikin samfuran fitsari, yawan su ya kasance ƙasa da yawan sinadarin mahaɗin iyaye (MOCA) a cikin samfuran iri ɗaya, wanda ke nuna cewa MOCA kanta ita ce babban nau'in da aka fitar a cikin fitsari kuma alama ce mai inganci ta fallasa.

Gabaɗaya, sakamakon da aka samu daga wannan babban kimantawar fallasa ga ma'aikata ya bayyana a fili cewa ya nuna daidaito da daidaiton matakan fallasa MOCA na ma'aikatan da aka yi bincike a kansu, saboda matakan fitar da iskar da aka gano suna da alaƙa da yanayin aikinsu, tsawon lokacin fallasa, da yanayin yanayin aiki. Bugu da ƙari, wani muhimmin abin lura daga binciken shine cewa bayan an kammala tantancewar nazari kuma an aiwatar da matakan kariya a wuraren aiki - kamar inganta tsarin iska, haɓaka amfani da kayan kariya na mutum (PPE), ko inganta ayyukan tsari - matakan fitar da fitsari na MOCA a cikin ma'aikatan da abin ya shafa sau da yawa sun nuna raguwa a bayyane kuma mai mahimmanci, yana nuna tasirin waɗannan hanyoyin rigakafi wajen rage fallasa ga MOCA a wurin aiki.