Glutaraldehyde Technological Frontier: Nasara a Fasahar Anti-Calcification

A cikin filin da ke damun zuciya, an dade ana amfani da glutaraldehyde don kula da kyallen jikin dabba (kamar bovine pericardium) don samar da bawuloli na bioprosthetic. Koyaya, ragowar ƙungiyoyin aldehyde masu kyauta daga tsarin al'ada na iya haifar da ƙididdigewa bayan dasa shuki, yana lalata dorewar samfuran.

Da yake magance wannan ƙalubalen, sabon binciken da aka buga a watan Afrilu 2025 ya gabatar da wani sabon salo na maganin maganin ƙididdiga (sunan samfur: Periborn), yana samun ci gaba mai ban mamaki.

1. Babban Haɓaka Fasaha:

Wannan bayani yana gabatar da mahimman ci gaba da yawa ga tsarin haɗin giciye na glutaraldehyde na gargajiya:

Haɗin Haɗin Kan Maganin Maganin Halitta:
Ana yin haɗin haɗin Glutaraldehyde a cikin wani kaushi na halitta wanda ya ƙunshi 75% ethanol + 5% octanol. Wannan tsarin yana taimakawa wajen cire phospholipids nama yadda ya kamata yayin haɗin giciye-phospholipids shine farkon wuraren ƙaddamar da ƙwayoyin cuta.

Wakilin Cike Sarari:

Bayan haɗe-haɗe, ana amfani da polyethylene glycol (PEG) azaman wakili mai cika sararin samaniya, yana kutsawa cikin gibba tsakanin filaye na collagen. Wannan duka suna garkuwa da wuraren ɓoye na hydroxyapatite lu'ulu'u kuma yana hana shigar da calcium da phospholipids daga plasma mai masaukin baki.

Rufe Tasha:

A ƙarshe, jiyya tare da glycine yana kawar da ragowar, ƙungiyoyin aldehyde masu amsawa, don haka kawar da wani mahimmin abu wanda ke haifar da ƙididdiga da cytotoxicity.

2.Sakamako na Musamman na Clinical:

An yi amfani da wannan fasaha a kan ɓangarorin ƙwayar ƙwayar ƙwayar ƙwayar cuta mai suna "Periborn." Wani bincike na asibiti wanda ya shafi marasa lafiya 352 sama da shekaru 9 ya nuna 'yanci daga sake aiki saboda al'amurran da suka shafi samfurin da ya kai 95.4%, yana mai tabbatar da ingancin wannan sabon dabarun rigakafin ƙididdiga da ƙaƙƙarfan dorewa na dogon lokaci.

Muhimmancin Wannan Ci gaban:

Ba wai kawai yana magance ƙalubalen da ya daɗe a fagen bawul ɗin bioprosthetic ba, yana faɗaɗa tsawon rayuwar samfur, amma kuma yana shigar da sabon kuzari cikin aikace-aikacen glutaraldehyde a cikin manyan kayan aikin ƙwayoyin cuta.