Gabar Fasaha ta Glutaraldehyde: Nasara a Fasahar Hana Calcification

A fannin dashen zuciya da jijiyoyin jini, an daɗe ana amfani da glutaraldehyde don magance kyallen dabbobi (kamar na shanu pericardium) don samar da bawuloli na bioprosthetic. Duk da haka, ragowar ƙungiyoyin aldehyde marasa amfani daga hanyoyin gargajiya na iya haifar da calcification bayan dasawa, wanda ke lalata dorewar samfuran na dogon lokaci.

A magance wannan ƙalubalen, wani sabon bincike da aka buga a watan Afrilun 2025 ya gabatar da sabon maganin hana ƙwayoyin calcium (sunan samfurin: Periborn), wanda ya sami ci gaba mai ban mamaki.

1. Ingantaccen Fasaha na Musamman:

Wannan maganin yana gabatar da wasu muhimman ci gaba ga tsarin haɗin gwiwar glutaraldehyde na gargajiya:

Haɗin Haɗin Halittar Halitta:
Ana yin haɗin Glutaraldehyde a cikin wani sinadari mai narkewa wanda ya ƙunshi kashi 75% na ethanol + 5% octanol. Wannan hanyar tana taimakawa wajen cire phospholipids na nama yadda ya kamata yayin haɗin giciye - phospholipids sune manyan wuraren nucleation don kalsiya.

Wakilin Cika Sarari:

Bayan haɗakar sinadarai, ana amfani da polyethylene glycol (PEG) a matsayin abin da ke cike sararin samaniya, yana shiga cikin gibin da ke tsakanin zaruruwan collagen. Wannan duka yana kare wuraren nucleation na lu'ulu'u na hydroxyapatite kuma yana hana shigar calcium da phospholipids daga plasma mai masaukin baki.

Rufe Tashar:

A ƙarshe, magani da glycine yana kawar da ragowar ƙungiyoyin aldehyde marasa amsawa, ta haka yana kawar da wani muhimmin abu da ke haifar da sinadarin kalsiyum da guba a jiki.

2. Sakamakon Gwaji na Asibiti:

An yi amfani da wannan fasaha a kan wani sifa na zuciya mai suna "Periborn." Wani bincike na asibiti da ya shafi marasa lafiya 352 sama da shekaru 9 ya nuna 'yancin sake yin tiyata saboda matsalolin da suka shafi samfur har zuwa kashi 95.4%, wanda ya tabbatar da ingancin wannan sabuwar dabarar hana kalsiyum da kuma dorewarta ta dogon lokaci.

Muhimmancin Wannan Nasara:

Ba wai kawai yana magance ƙalubalen da aka daɗe ana fuskanta a fannin bawuloli na bioprosthetic ba, yana ƙara tsawon rayuwar samfurin, har ma yana ƙara sabbin kuzari ga amfani da glutaraldehyde a cikin kayan aikin likitanci masu inganci.